WELCOME
FROM BENCHSIDE TO BLADESIDE
The SurgiCAL ProtEomics Laboratory (SCALPEL) was commissioned in February 2018 in the Institute for Health Innovation and technology (iHealthtech), NUS. Using a multidisciplianry approach, our aim is to translate scientific breakthroughs into tangible improvements in patient outcomes. Using a combination of mass spectrometry imaging, proteomics and primary patient derived organiod culture, our research is targeted towards improving the efficacy, safety and precision of chemotherapy, as well as development of mass spectrometry based platforms for real-time pathological and surgical analysis with an emphasis on pancreatic ductal adenocarcinoma (PDAC) and hepatocellular carcinoma (HCC).
OUR RESEARCH
INDUSTRY PARTNERSHIP
In 2019, SCALPEL signed a landmark research collaboration agreement with Bruker, giving us access to state-of-the art mass spectrometry (MS) technologies such as rapifleX®, nanoElute and maXis Plus for the development of MS tissue imaging and proteomics platforms.
MALDI IMAGING
MALDI imaging is mass spectrometry driven molecular histology, able to directly overlay MS profiles in pixels over tissue. making it versatile solution for visualizing distribution of targeted compounds, or for spatial biomarker discovery
MALDI MOLECULAR WEIGHT DETERMINATION
Matrix assisted laser desorption ionization (MALDI) is a soft ionization technique allowing for ionisation without fragmentation and coupled with TOF/TOF MS, can detect and identify a wide range of biomolecules.
SHOTGUN PROTEOMICS
Proteins are the drivers of a cells function. Through the use of proteomics technology to study all proteins in a biological system, we are able to get a global snapshot of the state of the system. this makes it an ideal technique for many applications such as unbiased biomarker discovery.
CONTACT US
MD6 #14-02 – Centre for Translational Medicine
Yong Loo Lin School of Medicine
National University of Singapore
Singapore 117599
